P286 Combined F18-FDG-PET-MRI-imaging: A promising tool for diagnostics of small bowel Crohn’s disease

Abstract Background Diagnostics of small bowel Crohn’s disease (CD) may be difficult. Combined PET-MRI has been documented to a reliable tool for evaluating intestinal metabolism, but clinical use limited due accessibility, costs and lack standardized methods quantify inflammation. Our study aims prove that combined can used detect active CD inflammation in bowel. Methods 25 patients with suspected ileal ileocolonoscopy were recruited from Turku University Hospital’s outpatient clinic. The patients’ endoscopic findings ileum graded according SES-CD- score (Simple Endoscopic Score disease). A static was obtained [18F]-FDG (fluorodeoxyglucose) tracer gadolinium contrast agent (Dotarem®). Hemoglobin (Hb), C-reactive protein (CRP), serum albumin (Alb) fecal calprotectin (FC) measured. After PET-MRI, capsule endoscopy done the along CECDAI-system (Capsule Endoscopy Activity Index). patient’s symptoms scored validated questionnaire. Medication data also collected. MR images protocol diffusion weighted imaging (DWI) analyzed degree on visual scale 1-4, none severe by an experienced abdominal radiologist. SUVmax (standardized uptake value) measured PET-sequences each patient terminal ileum. Results Twenty (80%) diagnosed had mean 3.40 (±1.54), while 20% without diagnosis lower 2.15 (± 0.93) (p=0.047). Patients who later treated immunomodulators or biologics higher than didn’t need medication oral budesonide only (3.71 (±1.49) vs 2.07 (±0.82), p=0.0093). There correlation MRI grading, CECDAI-score, SES-CD-score FC (r=0.406, p=0.049; r=0.504, p=0.056; r=0.419, p=0.042 r=0.49, p=0.014 respectively). correlated negatively Alb (r=0.599, p=0.0025) not Hb, CRP symptom patients. Conclusion In this we have shown could prediction progression. SES-CD-score, albumin. These suggest future diagnostics CD. Further analyses are needed define threshold values intestine